Dynamic analysis of MR-PET data on brain tumors

Institute of Biophysics and Biomedical Engineering, Faculty of Sciences, University of Lisbon, Portugal The introduction of hybrid MR-PET scanners offers new perspectives to better correlate MR and PET data with respect to time and space domain. In case of brain tumor patients, dynamic susceptibility contrast (DSC)-MRI is often used to measure perfusion levels of brain, while dynamic [F]-fluoro-ethyl-tyrosine (FET)-PET provides additional functional information. The dynamic analysis of data is becoming more relevant, rather than static analysis, and with this the extraction of parametric images. In this context, the aim of this work is to compare dynamic MR-PET data based on different features. A FET-PET scan was carried out on the 3T-MR-BrainPET [1] on each patient. Data was acquired for 60 min after injection in list-mode and reconstructed using OSEM3D software (4 subsets, 32 iterations). All MRI sequences were acquired simultaneous to the PET measurement. In this work, MPRAGE and DSC-MRI based on an EPI sequence images are used. For the dynamic analysis, data was co-registered and the same parameters were extracted, with Matlab, from MR-PET data to produce peak, time to peak (TTP), area under the curve (AUC) and wash-in parametric images. Results from 3 of the analyzed datasets from patients with brain tumors are presented on Figure 1. MPRAGE, DSC-MRI EPI sequence and FET-PET images and the extracted parametric images are shown. In FET-PET parametric images an uptake area can be identified in the region of morphological changes in anatomical MR. The parametric images provide extra information in addition to the summed FET-PET images. The time curves obtained from a gray-matter region defined on MPRAGE are presented on Figure 2. The extracted parametric images from dynamic MR-PET showed good spatial and temporal agreement (Figure 1). These results suggest that dynamic MR-PET may have extra information about biology and that the combination of simultaneous acquisition and analysis may be beneficial. Morgado et al. EJNMMI Physics 2014, 1(Suppl 1):A56 http://www.ejnmmiphys.com/content/1/S1/A56